Brand Name: Prepulsid
Generic Name: Cisapride
For: Cats, Dogs, and Horses
What is Cisapride?
Cisapride is a medication used to enhance the movement of the gastrointestinal (GI) system to treat conditions such as stasis, reflux, and constipation/megacolon. It is also used to treat Post-operative ileus (POI) in horses. POI is a common and serious complication in horses that have had abdominal surgery.
What if I miss giving my pet the medication?
If you miss a dose, give it when you remember, but if it is close to the time for the next dose, skip the dose you missed and give it at the next scheduled time, and return to the regular dosing schedule. Never give your pet two doses at once or give extra doses.
Are there any potential side effects?
Side effects are uncommon but vomiting, diarrhea, or gastrointestinal discomfort may occur. More serious side effects include incoordination, excessive drooling, muscle twitches, agitation, abnormal behavior, increased body temperature, and seizures; these signs may indicate doses are too high.
This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.
Are there any risk factors for this medication?
Cisapride should not be used in pets that are allergic to it or in pets with conditions that may be worsened by increased gastrointestinal movement, such as GI perforation, obstruction, or bleeding. It should not be used during pregnancy unless the benefits significantly outweigh the risks and should be used cautiously in lactating pets or pets with severe liver disease or abnormal heart rhythms.
Are there any drug interactions I should be aware of?
The following medications should be used with caution when given with cisapride: anticholinergic agents, benzodiazepines, cyclosporine, warfarin, oral drugs with a narrow therapeutic index, amiodarone, antifungals, chloramphenicol, cimetidine, fluvoxamine, macrolide antibiotics (except azithromycin), clarithromycin, fluoroquinolones, procainamide, quinidine, sotalol, and tricyclic antidepressants.
What should I do in case of emergency?
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.
